Handbook_Volume III

285 ietic stem cell transplantation. Sci Rep 2021;11:14307. https://doi. org/10.1038/s41598-021-93571-4 [27] Weber D, Jenq RR, Peled JU, Taur Y, Hiergeist A, Koestler J, et al. Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant 2017;23:845–52. https://doi.org/10.1016/j.bbmt.2017.02.006 [28] Lehrnbecher T, Averbuch D, Castagnola E, Cesaro S, Ammann RA, Garcia-Vidal C, et al. 8th European Conference on Infections in Leukaemia: 2020 guidelines for the use of antibiotics in paediatric patients with cancer or post-haematopoietic cell transplantation. Lancet Oncol 2021. https://doi.org/10.1016/s14702045(20)30725-7 [29] Bekker V, Zwittink RD, Knetsch CW, Sanders IMJG, Berghuis D, Heidt PJ, et al. Dynamics of the Gut Microbiota in Children Receiving Selective or Total Gut Decontamination Treatment during Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant 2019;25:1164–71. https://doi.org/10.1016/j. bbmt.2019.01.037 [30] Zama D, Gori D, Muratore E, Leardini D, Rallo F, Turroni S, et al. Enteral versus Parenteral Nutrition as Nutritional Support after Allogeneic Hematopoietic Stem Cell Transplantation: a Systematic Review and Meta-Analysis. Transplant Cell Ther 2021;27:180.e1-180.e8. https://doi.org/10.1016/j.jtct.2020.11.006 [31] D’Amico F, Biagi E, Rampelli S, Fiori J, Zama D, Soverini M, et al. Enteral Nutrition in Pediatric Patients Undergoing Hematopoietic SCT Promotes the Recovery of Gut Microbiome Homeostasis. Nutrients 2019;11:2958. https://doi.org/10.3390/nu11122958 [32] Yoshifuji K, Inamoto K, Kiridoshi Y, Takeshita K, Sasajima S, Shiraishi Y, et al. Prebiotics protect against acute graft-versushost disease and preserve the gut microbiota in stem cell transplantation. Blood Adv 2020;4:4607–17. https://doi.org/10.1182/ bloodadvances.2020002604 [33] Gorshein E, Wei C, Ambrosy S, Budney S, Vivas J, Shenkerman A, et al. Lactobacillus rhamnosus GG probiotic enteric regimen does not appreciably alter the gut microbiome or provide protection against GVHD after allogeneic hematopoietic stem cell transplantation. Clin Transplant 2017;31:e12947. https://doi. org/10.1111/ctr.12947 [34] Robin F, Paillard C, Marchandin H, Demeocq F, Bonnet R, Hennequin C. Lactobacillus rhamnosus Meningitis following Recurrent Episodes of Bacteremia in a Child Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. J Clin Microbiol 2010;48:4317–9. https://doi.org/10.1128/JCM.00250-10 [35] Pession A, Zama D, Muratore E, Leardini D, Gori D, Guaraldi F, et al. Fecal Microbiota Transplantation in Allogeneic Hematopoietic Stem Cell Transplantation Recipients: A Systematic Review. J Pers Med 2021;11. https://doi.org/10.3390/jpm11020100 [36] DeFilipp Z, Bloom PP, Torres Soto M, Mansour MK, Sater MRA, Huntley MH, et al. Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant. N Engl J Med 2019:NEJMoa1910437. https://doi.org/10.1056/NEJMoa1910437 [37] Ingham AC, Kielsen K, Mordhorst H, Ifversen M, Aarestrup FM, Müller KG, et al. Microbiota long-term dynamics and prediction of acute graft-versus-host disease in pediatric allogeneic stem cell transplantation. Microbiome 2021;9:148. https://doi. org/10.1186/s40168-021-01100-2 4.Aspetti clinici ed assistenziali trasversali

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